PDRN (PolyDeoxyRiboNucleotides) are DNA fragments typically derived from fish, often salmon or trout, Dr. Hall: “It has a well-established history in the medical world—particularly for its role in supporting tissue regeneration and wound healing.” PDRN first rose to fame in South Korea through in‑clinic treatments such as injectables and skin boosters, where doctors noticed how quickly patients’ skin healed and how luminous it looked afterward, according to According to Shinny Cho, MD, Korean consultant dermatologist at Future Care Medical.
“What sets PDRN apart is its ability to restore and regenerate the skin at a deeper level,” Dr. Hall says. “Unlike typical actives like hydrators or exfoliants, it supports the skin’s natural repair processes without needing deep penetration, as retinoids or peptides do.” PDRN not only addresses fine lines but also helps heal and repair, making it perfect for supporting the skin’s ability to regenerate and maintain its integrity over time, she explains.