This serum earns the top spot because it balances efficacy with comfort. Ariel Ostad, MD, a board-certified dermatologist in New York City, recommends it for beginners since it pairs retinol with niacinamide and hyaluronic acid, two ingredients that help minimize dryness and irritation. The formula itself is lightweight, hydrating, and absorbs quickly. After application, the skin is left moisturized and fresh, not stripped or dried out. It plays well with other skincare ingredients, so you won’t have to worry about pilling, either.
In testing, we found it noticeably improved skin clarity and smoothness within a few weeks. It layered seamlessly with moisturizer and sunscreen without pilling and delivered visible brightening with consistent use. Though it’s pricier than some options here, the results and tolerability justify the investment for first-time users.
“It has become a new staple in my collection. It does a great job of balancing both my oily areas and dry areas, and never leaves me feeling stripped or tight. The formula is quite hydrating and has already made a difference in the areas where I deal with acne scars most, particularly around my nose. I’ve been using it for around two weeks now and can confirm that the area is a lot more clarified and smooth.” —Alanna Martine Kilkeary, Glamour commerce writer
- Best for: All skin types, especially combination and sensitive
- Key ingredients: Retinol, niacinamide, hyaluronic acid
- Size: 1 fl. oz.
- Percentage: 0.3%
Best Drugstore: CeraVe Resurfacing Retinol Serum
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Original photo from Jenifer Calle testing CeraVe Resurfacing Retinol Serum
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Original photo from Jenifer Calle testing CeraVe Resurfacing Retinol Serum
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Original photo from Alanna Martine Kilkeary testing CeraVe Resurfacing Retinol Serum
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CeraVe Resurfacing Retinol Serum
Original video from Alanna Martine Kilkeary testing CeraVe Resurfacing Retinol Serum
Original video from Jenifer Calle testing CeraVe Resurfacing Retinol Serum
For an affordable entry point, this formula that boosts collagen production is a standout. “This retinol serum is formulated as an encapsulated retinol to reduce the appearance of fine lines and dullness,” says Dr. Garshick. Encapsulation allows for gradual release, helping reduce irritation while still delivering smoothing benefits. It contains niacinamide to help soothe skin and correct uneven skin tone, hyaluronic acid to plump fine lines, and ceramides to help strengthen the skin barrier and deliver all-day hydration.